Pancreatoduodenectomy (Whipple’s Procedure)

About

The pancreas is an organ roughly the shape and size of a medium carrot that lies deep in the upper abdomen. It has two major roles:

  • Production of hormones such as insulin (which regulates blood sugar levels)
  • Production of a juice containing enzymes that helps digest food

Indications

Pancreatoduodenectomy is performed for cancers of the head of the pancreas, distal bile duct or ampulla and some duodenal cancers. The operation is also performed for some pancreatic neuroendocrine tumours and cysts of the pancreas that are at high risk of developing into cancer.

The operation involves

Pancreatoduodenectomy is a major operation that involves removal of the head and uncinate of the pancreas, bile duct, gallbladder and duodenum. After removal, the upper cut end of the bile duct, the cut end of the pancreas and the stomach or short remaining segment of the duodenum are joined (anastomosed) to the bowel.

Potential complications

Complications of pancreatoduodenectomy include:

  • Bleeding
  • Leak of pancreatic juice, bile or fluid from the gut from one of the joins
  • Delayed gastric emptying (slow return of the stomach’s ability to digest food and empty)
  • Diabetes (or worsening of diabetes if already diabetic)
  • Malabsorption (due to insufficient pancreatic enzymes to digest food)

Other risks include general risks of major surgery such as blood clots in the legs (deep venous thrombosis) that can travel to the lungs (pulmonary embolism), infections and cardiac and respiratory problems.

Considerations

With modern pancreatic surgery, serious life-threatening complications are uncommon although less serious, manageable complications do occur frequently. Your individual risk will be discussed with you prior to surgery.

Hospital stay and aftercare

Most patients stay in hospital about two weeks after pancreatoduodenectomy although it usually takes several months to fully regain strength and energy after surgery. Return to normal stomach function takes some time and patients need to modify their diet, eating smaller more frequent meals. Creon (pancreatic enzyme replacement capsules) usually need to be taken with meals long term to help digest food.

This information is created and published online for informational purposes only. It is not intended to be a substitute for individual professional medical advice and should not be used to make decisions about your health, diagnosis or treatment.